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Case report
Massive juvenile ossifying fibroma arising from the middle turbinate
  1. Valentinos Sofokleous1,2,
  2. Konstantina Chrysouli1,
  3. Efthymios Kyrodimos1 and
  4. Evangelos Giotakis1
  1. 11st Department of Otorhinolaryngology – Head & Neck Surgery, University of Athens Medical School, Athens, Greece
  2. 2Department of Pediatric Otorhinolaryngology, Athens Children's Hospital "P. & A. Kyriakou", Athens, Greece
  1. Correspondence to Valentinos Sofokleous; sofokleousv{at}


A 19-year-old man presented with a long-standing history of nasal obstruction, which gradually became worse over the past 2 years. Nasal endoscopy revealed a sizeable rounded mass covered by a normal-looking mucosa. Imaging studies showed a mass arising from the left middle turbinate that extended throughout the expanse of the anterior skull base. The tumour was resected via an endoscopic endonasal approach. Histopathological examination revealed a psammomatoid juvenile ossifying fibroma. The patient remains free of recurrence after almost 3 years of follow-up. Only four cases of ossifying fibroma with middle turbinate localisation have been reported in the literature so far, with our case representing the fifth and most extensive case. Clinical, radiological and histological findings should all be considered for establishing the correct diagnosis. An endoscopic approach represents an excellent therapeutic option. Long-term clinical and radiological surveillance is required due to the risk of recurrence.

  • ear, nose and throat/otolaryngology
  • head and neck surgery
  • oral and maxillofacial surgery
  • otolaryngology / ENT

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  • Contributors All authors are part of the team managing the case. EG was the attending physician in chief and primary surgeon. He also guided manuscript writing and preparation. VS and KC reviewed and appraised the existing literature. VS wrote a first draft that was critically revised following comments from the rest of the authors. EK contributed by critically revising the article. All authors approved the final version of the document.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.