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Case report
IgG4-related pancreatitis: an uncommon cause of hyperglycaemia
  1. David M Williams1,
  2. Asif Nawaz1,
  3. Brijesh Srivastava2 and
  4. Lindsay George1
  1. 1Department of Diabetes & Endocrinology, University Hospital Llandough, Cardiff, UK
  2. 2Department of Gastroenterology, University Hospital of Wales, Cardiff, UK
  1. Correspondence to Dr David M Williams; david.williams{at}


Hyperglycaemia is one of the most common metabolic disturbances encountered in clinical practice, with an important differential diagnosis. We report a case of a 72-year-old woman referred to diabetes services with rapidly increasing blood glucose and weight loss despite oral hypoglycaemic therapy. She reported mild upper abdominal discomfort and liver function tests were deranged, prompting further investigation. Abdominal imaging demonstrated a diffusely enlarged pancreas and subsequent investigations noted a markedly raised serum IgG4. She was diagnosed with IgG4-related pancreatitis and swiftly responded to steroid therapy. Secondary causes of diabetes should be considered in people with atypical presentation such as weight loss or rapid progression to insulin use. While IgG4-related disease is rare, its varied clinical presentation as a result of its multiorgan involvement requires a high index of suspicion. This case highlights the importance of a detailed diagnostic work-up and describes an unusual clinical presentation of this increasingly recognised multisystem disease.

  • diabetes
  • pancreatitis
  • immunology

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  • Contributors DMW and AN planned and wrote the manuscript. The patient was under the care of BS and LG, who critically reviewed the manuscript and were involved with the revision process.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.