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Case report
Long-lasting clinical, radiological and immunological remission of severe nasal polyposis by means of ‘reboot’ surgery
  1. Luca Malvezzi1,
  2. Francesca Pirola1,
  3. Armando De Virgilio1 and
  4. Enrico Heffler2,3
  1. 1Otorhinolaryngology, Humanitas Clinical and Research Center, Rozzano, MI, Italy
  2. 2Biomedical Sciences, Humanitas University, Pieve Emanuele, TO, Italy
  3. 3Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, Rozzano, MI, Italy
  1. Correspondence to Dr Enrico Heffler; heffler.enrico{at}


A 68-year-old woman with a long history of relapsing chronic rhinosinusitis with nasal polyps (CRSwNP) underwent a complete reboot surgery and nasal biopsy prior to and after surgery. Remarkable improvement of symptoms and no signs of mucosal oedema and no complaints of initially worsening nasal functions were still present 12 months after reboot surgery. Biopsy demonstrated an outstanding reduction in eosinophilic infiltration and re-epithelisation of nasal mucosa with normal features after reboot approach compared with previous surgeries. Therefore, reboot approach may become an effective instrument in plurioperated patients with CRSwNP who suffer from a nasal condition that is recalcitrant to pharmacological therapies and is unsatisfactorily treated by standard surgical techniques.

  • nasal polyps
  • otolaryngology / ENT

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  • Contributors LM and FP evaluated and surgically treated the patient. ADV contributed in interpreting the results. EH contributed in analysing and interpreting the results. All the authors contributed in writing the report and approved it.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.