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Case report
Grade I meningioma with disseminated bone disease: a rare clinical phenomenon
  1. Oriol Mirallas,
  2. David Marmolejo,
  3. Augusto Valdivia and
  4. Maria Vieito
  1. Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain
  1. Correspondence to Oriol Mirallas; urimirallas{at}


Meningioma, the second most common primary tumour of the central nervous system, is classified into three different grades based on their characteristics. Each tumour grade includes different molecular subtype, growth potential, and thus, different prognosis. Grade I meningioma is the most common subtype with a benign course, in which systemic dissemination rarely occurs. We present the case of a 48-year-old male patient with a history of grade I meningioma who was referred 3 years after the initial diagnosis to our centre due to pelvic pain. Computed tomography (CT) images showed new pelvic bone lesions whose histopathological report was compatible with a grade I meningioma. Neither hormonal therapy concomitant with octreotide nor hydroxiurea treatments were effective. Very little is known about this entity’s prevalence and treatment when disseminated disease occurs. Thus, we think it is important to increase the positive and negative clinical experiences in this setting.

  • CNS cancer
  • neurosurgery
  • neurooncology
  • radiotherapy
  • cancer - see oncology

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  • Contributors DM and AV have made the acquisition and analysis of the clinical data. OM, DM and AV drafted and critically revised the work. OM reviewed the full text and summarised each section. The final approval, review and mentorship were provided by MV.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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