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Case report
Atraumatic idiopathic splenic rupture induced by granulocyte-colony stimulating factor (G-CSF) for the treatment of pancytopenia, managed successfully by laparoscopic splenectomy
  1. Ugochukwu Chinyere Chinaka,
  2. Joshua Fultang,
  3. Jelizaveta Pereca and
  4. Abdulmajid Ali
  1. General Surgery, University Hospital Ayr, Ayr, UK
  1. Correspondence to Professor Abdulmajid Ali; abdulmajidali{at}


Splenic rupture is a potentially life-threatening condition and an uncommon short-term complication of granulocyte-colony stimulating factor (G-CSF) administration. It may present as acute abdominal pain or suddenly precipitously worsening anaemia with haemodynamic instability that requires urgent operative intervention for survival. We present a case of an atraumatic idiopathic splenic rupture in University Hospital, Ayr in a patient who received G-CSF treatment for chemotherapy-induced (methotrexate) pancytopenia and was successfully managed by laparoscopic splenectomy.

  • haematology (incl blood transfusion)
  • gastrointestinal surgery
  • general surgery

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  • UCC and JF are joint first authors.

  • Contributors UCC and JF co-authored the case report. They both conceived the topic and were involved in the research and write-up. JP was involved in the research. AA performed the surgery and reviewed the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.