Article Text

Download PDFPDF
Case report
Failure of platelet function analyser 200 to demonstrate clinical clopidogrel resistance in a patient undergoing intracranial vascular stenting
  1. Hayden Bell1,
  2. Brendan Steinfort1,2,
  3. Leonardo Pasalic3 and
  4. Mark Dexter1
  1. 1Neurosurgery, Westmead Hospital, Sydney, New South Wales, Australia
  2. 2Neurosurgery, Royal North Shore Hospital, Sydney, New South Wales, Australia
  3. 3Haematology, Westmead Hospital, Sydney, New South Wales, Australia
  1. Correspondence to Dr Hayden Bell; hayden.f.bell{at}


A patient undergoes intracranial stent insertion for stent-assisted coiling of a basilar tip aneurysm and left middle cerebral artery aneurysm. A flow diverting stent is also placed across an anterior communicating artery aneurysm. Prior to the procedure, the patient takes dual antiplatelet medications, being aspirin and clopidogrel. Because of the concern regarding in-stent thrombus and thromboembolic complications related to intracranial stenting and the high rate of clopidogrel resistance, preoperative platelet function testing (PFT) was undertaken to ensure platelet inhibition. In this case, PFT was performed on a platelet function analyser which demonstrated platelet inhibition. Ten days following the procedure, the patient represented with thromboembolic stroke. Repeat PFT performed with whole blood impedance aggregometry and despite full medication compliance demonstrated clopidogrel resistance. Clopidogrel was then ceased and prasugrel commenced. This case demonstrates the importance of appropriate platelet inhibition in patients with intracranial stents and the controversy surrounding PFT.

  • neurosurgery
  • interventional radiology
  • radiology
  • unwanted effects / adverse reactions
  • stroke
View Full Text

Statistics from


  • Contributors BS performed the surgery on the patient the case report is based on. HB researched/wrote the case report. BS, LP and MD then provided specialist input in editing the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.