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Case report
Steroids as rescue therapy for vitamin A-induced acute liver failure
  1. Anand V Kulkarni1,
  2. Pramod Kumar1,
  3. Rupjyoti Talukdar2 and
  4. Nagaraj P Rao1
  1. 1Department of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India
  2. 2Department of Pancreatology, Asian Institute of Gastroenterology, Hyderabad, India
  1. Correspondence to Dr Anand V Kulkarni; anandvk90{at}


Antioxidant drugs form one of the mainstay therapies for pain management in chronic pancreatitis. Heightened oxidative stress and free radical activity is the target for the use of antioxidant therapy in chronic pancreatitis pain relief. One of the chief components of these drugs is beta-carotene, and vitamin A. Vitamin A is a proven hepatotoxic agent which can lead to liver injury ranging from acute hepatitis to cirrhosis. Here, we present a case of chronic pancreatitis who continued antioxidant therapy unsupervised for 7 years and developed vitamin A-induced acute liver failure, which was treated with prednisolone.

  • gastrointestinal system
  • pancreatitis
  • liver disease
  • contraindications and precautions

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  • Contributors AVK and PK made the study concept and design; image collection/graphs by AVK and PK; compilation and critical revision by AVK, RT and NPR. All members approved the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.