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Case report
Suspected adverse reaction to compounded preparations prescribed for weight loss: two cases of cerebral venous thrombosis
  1. Beatrice Mainoli1,2,
  2. Mariana Carvalho Dias3,
  3. Patricia Canhão3,4 and
  4. Mário Miguel Rosa1,2,4,5
  1. 1Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
  2. 2Unidade de Farmacovigilância de Lisboa, Sistema Nacional de Farmacovigilância, Lisboa, Portugal
  3. 3Stroke Unit, Neurology Department, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal
  4. 4Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
  5. 5Neurology Department, Department of Neurosciences and Mental Health, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal
  1. Correspondence to MD Mariana Carvalho Dias; marianamoraisdias{at}gmail.com

Abstract

We report two cases of cerebral venous thrombosis associated with the use of compounded preparations containing several active substances prescribed for weight loss. In both cases there is suspicion of additive/synergic interaction with oral contraceptives. The adverse drug reactions were considered serious, being life-threatening and causing hospitalisation for days.

  • neurology (drugs and medicines)
  • drug misuse (including addiction)
  • safety
  • unwanted effects / adverse reactions
  • stroke
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Footnotes

  • BM and MCD are joint first authors.

  • BM and MCD contributed equally.

  • Contributors BM and MCD contributed equally to this paper, in interpretation of the data, drafting and revising the manuscript for intellectual content. PC and MMR revised the manuscript for intellectual content and approved the version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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