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Case report
Rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria
  1. Avirup Majumdar,
  2. Virendra Atam and
  3. Mayank Mishra
  1. Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
  1. Correspondence to Dr Avirup Majumdar; dr.a.majumdar99{at}gmail.com

Abstract

Chicken pox caused by varicella zoster virus is usually a self-limiting disease causing rare life-threatening complications. Involvement of the kidneys is infrequent during the course of the illness. Literature shows rare reports of acute glomerulonephritis following varicella infection. We report a case of 16-year-old boy presenting with anasarca with characteristic healed rashes of chicken pox. His urinalysis revealed a ‘massive’ nephrotic range proteinuria (16 g/24 hours), gross hematuria and pyuria. A percutaneous renal biopsy showed membranoproliferative glomerulonephritis. Most cases of post-varicella glomerulonephritis have been described in children, massive proteinuria of this range in an immunocompetent adolescent, being an extremely rare entity. Acute proliferative glomerulonephritis in such cases is usually an immune complex hypocomplementaemic glomerulonephritis in response to the zoster infection. Proteinuria in most patients is benign and self-limiting with few fatal reports of crescentic glomerulonephritis progressing to acute renal failure.

  • infections
  • nephrotic syndrome
  • proteinurea
  • acute renal failure
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Footnotes

  • Twitter @AvirupMajumdar

  • Contributors AM was involved in planning, review of literature, designing the case presentation and discussion with coauthors, programming, interpretation and analysis of data and correspondence with family members of the patient. VA was involved in planning, conception and design, interpretation of data, overall supervision and guidance. MM was involved planning, acquisition of data and interpretation of data and helping to bring out conclusion.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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