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Case report
Symptomatic hyponatremia: a rare but reversible adverse reaction of lubiprostone
  1. Tsuneo Takenaka,
  2. Mikio Zeniya,
  3. Soichiro Miura and
  4. Takahiro Amano
  1. Department of Medicine, Kokusai Iryo Fukushi Daigaku Daigakuin - Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan
  1. Correspondence to Professor Tsuneo Takenaka; takenaka{at}


Several intestinal secretagogues became available for the patients with irritable bowel syndrome. We report a case of symptomatic hyponatremia after lubiprostone ingestion. A male patient was visiting our office to manage chronic kidney disease. He suffered chronic hepatitis (type C), which was successfully treated with asunaprevir and daclatasvir. He took lubiprostone due to constipation, and then watery diarrhoea was frequently developed. Next morning, he came to our hospital due to consciousness disturbance. Physical examination showed dehydration and laboratory data exhibited hyponatremia (110 mEq/L). Subsequent treatment against hypovolemic hyponatremia recovered his consciousness without any sequels. This case suggests that intestinal secretagogues can accompany severe electrolyte disturbance. Potential mechanisms for hyponatremia were discussed.

  • drugs and medicines
  • hepatitis C
  • neurology
  • chronic renal failure

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  • Contributors TT performed conduct, reporting, acquisition and interpretation of the data. MZ did conduct, conception and design and interpretation of the data. SM performed reporting, conception and design and interpretation of the data. TA performed conduct, conception and design and interpretation of the data.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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