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Case report
Synchronous metaplastic breast carcinoma and lung adenocarcinoma: a rare case and review of the literature
  1. Rebecca Lane,
  2. Felicia Yan,
  3. Daniel Higgins and
  4. Gauri Agarwal
  1. Department of Medical Education, University of Miami Miller School of Medicine, Miami, Florida, USA
  1. Correspondence to Ms Felicia Yan; fyan{at}med.miami.edu

Abstract

Synchronous primary cancers occur in 1.7% of breast cancer cases and metaplastic breast cancer (MBC) occurs in less than 1% of breast cancer cases. We present a previously healthy 66-year-old woman diagnosed with MBC after surgical resection of a presumed cyst. A second primary cancer, multifocal lung adenocarcinoma, was discovered during the staging process for her MBC. Remarkably she had not experienced pulmonary or constitutional symptoms at the time of diagnosis. She received chemotherapy with paclitaxel and carboplatin, followed by immunotherapy with nivolumab. At 24 months of follow-up after her initial diagnosis, she was breast cancer-free with stable pulmonary nodules. This case highlights that rather than assuming multifocal lesions represent metastasis, biopsies should be considered as clinical management could be significantly altered in the presence of a synchronous cancer. Furthermore, platinum-based chemotherapy agents have potential to be considered in the treatment of MBC.

  • breast cancer
  • chemotherapy
  • lung cancer (oncology)
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Footnotes

  • RL and FY contributed equally.

  • Contributors All the authors meet authorship criteria. FY made substantial contributions to the design of the work and acquisition, analysis and interpretation of the data. RL made substantial contributions to the conception of the work and acquisition and analysis of the data. DH made substantial contributions to the conception of the work and acquisition, analysis and interpretation of the data. GA made substantial contributions to the conception of the work and interpretation of the data. FY had roles in drafting the work and revising it critically. RL had a role in drafting the work. DH and GA had roles in revising the work critically. All authors approve of the work to be published. All authors agree to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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