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Case report
Hyperparathyroidism in pregnancy
  1. Catherine Davis1 and
  2. Tanya Nippita1,2
  1. 1Faculty of Medicine and Health, The University of Sydney Northern Clinical School, St Leonards, New South Wales, Australia
  2. 2Department of Obstetrics and Gynaecology, Royal North Shore Hospital, Sydney, New South Wales, Australia
  1. Correspondence to Dr Catherine Davis; CatherineLouise.Davis{at}


Hyperparathyroidism is a rare disease during pregnancy, which has increased risks, including miscarriage and fetal growth restriction. However, the diagnosis of hyperparathyroidism is frequently not recognised or delayed as symptoms are non-specific and calcium is not routinely measured. With a thorough medical history and clinical suspicion, early diagnosis and treatment can reduce the risk of some pregnancy complications. A 35-year-old woman presented at 13/40 with hyperemesis gravidarum. She had elevated serum calcium and a parathyroid lesion on ultrasound. She underwent a parathyroidectomy with rapid normalisation of her calcium. Histopathology confirmed a parafibromin-deficient parathyroid tumour, suggestive of hyperparathyroidism jaw tumour syndrome. At 30/40, she presented with pre-eclampsia (hypertension, hyper-reflexia, proteinuria and intrauterine growth restriction) and had a caesarean section at 30+1/40, delivering a male infant, 897 g (fifth percentile). She had a prior 12-month history of chronic constipation and nephrolithiasis but was not investigated further despite elevated calcium (2.82 mmol/L).

  • pregnancy
  • endocrinology
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  • Contributors CD conceived the report and acquired the data under the guidance of TN. CD drafted the initial manuscript with TN and revised the manuscript critically. TN and CD both approve and take responsibility for the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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