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Radiation-induced glioblastoma of the conus medullaris from radiation treatment of cervical cancer
  1. Juan Silvestre Grecia Pascual1,
  2. Ibet Marie Yap Sih1,
  3. Joeanne Marie Mahinay Salise2 and
  4. Edwin Lim Munoz2
  1. 1Division of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines-Manila, Manila, Philippines
  2. 2Department of Laboratories, College of Medicine and Philippine General Hospital, University of the Philippines-Manila, Manila, Philippines
  1. Correspondence to Dr Juan Silvestre Grecia Pascual; jgpascual{at}


Radiation-induced spinal glioblastoma is an extremely rare disease with only four previously published reports in the literature. We report the fifth case, a 69-year-old woman who previously underwent treatment with brachytherapy for cervical cancer, and thereafter presented with neurologic deficits from a conus medullaris tumour. Biopsy and histopathology confirm glioblastoma, not otherwise specified. Treatment of spinal glioblastoma consists of surgery, either biopsy or excision and chemoradiation. However, results are still unsatisfactory and prognosis remains poor.

  • neurooncology
  • spinal cord
  • gynecological cancer
  • radiotherapy

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  • Contributors JSGP is the primary author and is in charge of the conceptualisation and writing of this work. IMYS is the supervising senior author in charge of overseeing the overall construction of the paper. JMS is the neuropathology resident, she contributed in reading and writing parts related to histopathology and diagnosing this case. EM is the senior supervising neuropathologist in charge of the case and oversaw the writing and reading of histopathologic parts of this paper. All authors agree to submission of the case report to BMJ Case Reports.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.