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Cerebral venous sinus thrombosis in a patient with concomitant Graves’ disease and squamous cell carcinoma of the cervix
  1. Yong Chuan Chee1,2 and
  2. Sanihah Abdul Halim1,2,3
  1. 1Department of Internal Medicine (Neurology), School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  2. 2Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  3. 3Brain and Behaviour Cluster, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
  1. Correspondence to Dr Sanihah Abdul Halim; sanihahabdhalim{at}


Cerebral venous sinus thrombosis (CVST) is caused by either acquired or inherited pro-thrombotic states. Hyperthyroidism is a less recognised predisposing factor of CVST, and the causality has been debated. We report a case of a life-threatening CVST in a 40-year-old woman, with uncommon dual risk factors: hyperthyroidism and advanced squamous cell carcinoma of the cervix. CVST should be considered as a differential diagnosis when a patient with hyperthyroidism presents with new-onset headache or other neurological symptoms. Further assessment to elucidate other covert risk factors may need to be continuously carried out, when the causal relationship of one apparent cause has not been well established.

  • stroke
  • thyrotoxicosis
  • gynaecological cancer

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  • Contributors YCC design and conceptualisation, acquisition and interpretation of the data, drafted the manuscript. SAH design and conceptualisation, analysed and interpreted the data, drafted and revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.