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Acrokeratosis paraneoplastica (Bazex syndrome) as the presenting sign of pancreatic adenocarcinoma
  1. Luke Horton1,
  2. Lisa M Bedford2 and
  3. Steven Daveluy2
  1. 1Wayne State University School of Medicine, Detroit, Michigan, USA
  2. 2Dermatology, Wayne State University School of Medicine, Dearborn, Michigan, USA
  1. Correspondence to Mr Luke Horton; luke.horton2{at}


Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic skin condition characterised by acral psoriasiform plaques, with a predilection for the nose, ears, hands and feet. It typically presents before the discovery of an internal malignancy and is often misdiagnosed as an inflammatory dermatitis that does not respond to treatment. It is associated with squamous cell carcinoma of the aerodigestive tract and lung, as well as adenocarcinoma of the lung, colon and gastrum. Here, we describe the second reported case of Bazex syndrome in the setting of pancreatic adenocarcinoma and the first such case in a patient of African ancestry.

  • dermatology
  • cancer intervention
  • pancreas and biliary tract
  • pancreatic cancer
  • screening (oncology)

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  • Contributors LH drafted the manuscript. LMB and SD edited the manuscript, providing critically important insights and expertise, and also played vital roles in the diagnosis and care of this patient. LMB and SD were responsible for diagnosing and treating the patient. All authors reviewed and approved the final manuscript and agree to be accountable for the article in all that it entails.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.