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Primary diffuse large B cell lymphoma (DLBCL) of the prostate presenting with lower urinary tract symptoms (LUTS)
  1. Ayesha Nusrat1 and
  2. Syed Muhammad Nazim2
  1. 1Pathology, Aga Khan University Hospital, Karachi, Pakistan
  2. 2Surgery (Urology Section), Aga Khan University Hospital, Karachi, Pakistan
  1. Correspondence to Dr Syed Muhammad Nazim; muhammad.nazim{at}


Malignant lymphomas of the prostate are very rare tumours and are generally not considered in the clinical or pathological diagnosis of prostatic enlargement. We report a case of a 56-year-old man who presented with long-standing history of low back pain and a 2-month history of voiding lower urinary tract symptoms. He denied any history of urinary retention, trauma, catheterisation or any constitutional symptoms. Examination revealed no lymphadenopathy and hepatosplenomegaly. Digital rectal examination showed an irregular, moderately enlarged nodular prostate. His prostate-specific antigen was 1.54 ng/mL. MRI of the pelvis did not show any focal lesion apart from abnormal signal intensity in the central zone. Bone scan was negative. Transrectal ultrasound-guided prostate biopsy revealed diffuse large B cell lymphoma. Bone marrow biopsy and whole body positron emission tomography/CT were unremarkable. The patient achieved complete remission after receiving six cycles of R-CHOP chemotherapy.

  • prostate
  • pathology
  • prostate cancer
  • malignant and benign haematology

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  • Contributors AN provided histopathology and immunohistochemistry images and description, performed the literature search and wrote the manuscript. SMN contributed to patient-related data including patient consent, literature search, writing of the manuscript and final review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.