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Twin pathologies: synchronous leiomyosarcoma and squamous cell carcinoma of the larynx
  1. Thomas Crotty,
  2. Emma Keane,
  3. Mel Corbett and
  4. Tom Moran
  1. Department of Otolaryngology/ Head and Neck Surgery, Mater Misericordiae University Hospital, Dublin, Ireland
  1. Correspondence to Dr Thomas Crotty; tcrotty92{at}


The synchronous discovery of leiomyosarcoma (LMS) and squamous cell carcinoma (SCC) of the larynx is extremely rare. We describe our experience of managing a patient with this unusual presentation. A 35-year-old man was initially diagnosed with advanced stage (T4bN1M0) laryngeal LMS. Neoadjuvant sarcoma-directed chemotherapy and radiation therapy allowed a successful pharyngolaryngo-oesophagectomy to be performed in an otherwise inoperable cancer. Histological examination of the resection specimen revealed poorly differentiated SCC, indicating the underlying diagnosis was a sarcomatoid carcinoma of the larynx. Considering our limited experience of managing synchronous LMS and SCC of the larynx, it is important to carefully evaluate the natural history, route of spread and pathological characteristics of both tumours, when determining treatment.

  • otolaryngology / ENT
  • head and neck cancer
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  • Contributors The patient was under TM, consultant ENT surgeon, whilst in hospital. EK collected the clinical data. TC and MC wrote the manuscript. All four authors assisted in reviewing and revising the manuscript prior to submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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