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Case report
Non-sebaceous lymphadenoma of the submandibular gland: diagnostic challenges in the head and neck cancer pathway
  1. Graham Garside1,
  2. Dominic Jaikaransingh2,
  3. Gayani Pitiyage3 and
  4. Enyinnaya Ofo4
  1. 1York Hospitals NHS Trust, York, North Yorkshire, UK
  2. 2St George's University of London, London, London, UK
  3. 3Pathology, St George's University Hospital NHS Foundation Trust, London, London, UK
  4. 4ENT-Head & Neck Surgery, St George's University Hospital NHS Foundation Trust, London, London, UK
  1. Correspondence to Mr Enyinnaya Ofo; enyinnaya.ofo{at}


Non-sebaceous lymphadenoma (NSLA) is a rare benign salivary gland tumour with lymphoid and epithelial components and without sebaceous differentiation. The large majority of the reported cases arise within the parotid gland. We present an NSLA arising from the submandibular gland. The tumour presented as a painless longstanding neck lump. Ultrasound, fine needle aspiration, MRI and positron emission tomography found features supportive of squamous cell carcinoma. The patient was treated with surgery for oropharyngeal carcinoma of unknown origin, in accordance with local and national guidelines. The final histological assessment revealed the level Ib neck lesion to be NSLA. Although a rare occurrence, these lesions may pose a diagnostic challenge in the head and neck cancer pathway.

  • pathology
  • otolaryngology / ENT

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  • Contributors GG conducted literature review, editing and writing of report. DJ undertook initial research of case, sourcing and writing case materials and reviewing manuscript. GP provided histopathology images with annotations, pathology reporting and specialist head and neck pathology review and recommendations, and reviewed manuscript, and was a pathologist involved in patient's care. EO provided specialist head and neck review and recommendations, reviewed the case and research, and was the surgeon involved in patient's care.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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