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Case report
Amyopathic dermatomyositis combined with peripheral neuropathy
  1. Zenshi Miyake1,
  2. Akiko Ishii1,
  3. Naoko Okiyama2 and
  4. Akira Tamaoka1
  1. 1Neurology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan
  2. 2Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan
  1. Correspondence to Dr Akiko Ishii; a_ishii{at}


We provide the first report of amyopathic dermatomyositis combined with peripheral neuropathy. Our patient, a 49-year-old woman, initially experienced muscle weakness and tingling sensations in her legs, and nerve conduction study findings and the detection of antiganglioside antibodies indicated that she had autoimmune peripheral neuropathy. The unexpected presence of skin lesions, interstitial pneumonia and antibodies to melanoma differentiation-associated protein 5 prompted an additional diagnosis of amyopathic dermatomyositis. No previous report has described amyopathic dermatomyositis with peripheral neuropathy, and the present case provides evidence for the once-controversial concept of neuromyositis.

  • dermatology
  • peripheral nerve disease
  • rheumatology

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  • Contributors ZM, AI and AT examined the patient using neurological, electrophysiological, imaging and laboratory tests. NO performed skin biopsy and measured anti-MDA5 antibody levels.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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