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Case report
Acute haemorrhagic oedema of infancy: a condition that is not always benign
  1. Ugo Cucinotta,
  2. Francesca Mazza,
  3. Giovanni Battista Pajno and
  4. Romina Gallizzi
  1. Department of Human Pathology in Adult and Developmental Age ‘Gaetano Barresi’, University of Messina, Messina, Sicilia, Italy
  1. Correspondence to Dr Romina Gallizzi; rgallizzi{at}


Acute haemorrhagic oedema of infancy (AHOI) is a rare condition and an unusual diagnosis for the paediatrician, as approximately 300 cases have been reported in literature so far. Although it was considered for years a less serious variant of Henoch-Schönlein purpura, nowadays it is thought to be a different entity, with his own characteristics and clinical outcome. In literature it is described as a benign condition, self-limiting and without any systemic involvement in most of the cases. We present an atypical case of AHOI with a severe presentation and which needed an aggressive and prolonged steroid therapy.

  • skin
  • dermatology
  • rheumatology
  • infant health
  • paediatrics
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  • Contributors All the authors followed the case during the hospitalisation of the patient and took part to the diagnostic process and to therapeutic choices. UC and RG conceived of the idea of describing the case. UC wrote the paper with the contribution of FM who dealt with collecting all the investigations results obtained during the hospitalisation and helped in the text development. In addition, RG contributed in performing differential diagnosis thanks to her experience in paediatric rheumatology and in conceiving the learning points. GBP was involved in planning the case report, provided critical revision of the article and provided final approval of the version to publish. All authors discussed the results and commented on the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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