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Interstitial pneumonia with autoimmune features in a patient with melanoma differentiation-associated gene 5 (MDA5) antibody
  1. Lih En Hong1,2,
  2. Susanna Proudman1,2 and
  3. Vidya Limaye1,2
  1. 1Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
  2. 2Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia
  1. Correspondence to Dr Lih En Hong; lihen.hong{at}


Melanoma differentiation-associated gene 5 (MDA5) antibody, also known as anti-CADM140 antibody is recognised to be associated with rapidly progressive interstitial lung disease, which can be fatal within 3 months. It is also known to be associated with amyopathic dermatomyositis. We report a case of MDA5 antibody-associated interstitial pneumonia with autoimmune features, without cutaneous features of dermatomyositis, in a Sudanese patient with dual positive antibodies to Ro52. The patient notably had several features associated with poor prognosis, including age, high serum ferritin level, anti-Ro52 antibodies and progressive lung infiltrates during treatment.

  • connective tissue disease
  • interstitial lung disease
  • radiology
  • lung function
  • immunology

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  • Contributors LEH, SP and VL were involved in the care of the patient being discussed. LEH performed literature review, prepared and formatted the manuscript of the case report. SP and VL edited, reviewed and formatted the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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