Article Text

Download PDFPDF
Case report
Undiagnosed fibromuscular dysplasia in a deceased donor kidney transplant successfully treated with angioplasty
  1. Edward Medeiros1,
  2. Reginald Gohh2 and
  3. Basma Merhi2
  1. 1Department of Nephrology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA
  2. 2Brown Medicine, Division of Nephrology and Hypertension, Division of Renal Transplantation, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA
  1. Correspondence to Dr Edward Medeiros; medeiros.eg{at}gmail.com

Abstract

A 41-year-old man with end-stage renal disease received a deceased donor kidney transplant without complication. Maintenance immunosuppression consisted of tacrolimus, mycophenolate and prednisone. Two months after transplantation, his creatinine did not improve beyond 2–2.3 mg/dL, which prompted allograft biopsy. His biopsy showed tubular epithelial injury without rejection, and given concern for possible calcineurin-inhibitor toxicity, his tacrolimus was changed to sirolimus. Renal function improved, but 1 month later he presented to the hospital with seizure activity, severe hypertension, acute kidney injury and MRI findings suggestive of posterior reversible encephalopathy syndrome. Blood pressure was difficult to control, which had not been the case in the immediate posttransplant period, and addition of lisinopril worsened his renal function. Transplant renal artery stenosis was suspected, and allograft ultrasound with doppler confirmed our suspicion. The patient underwent an angiogram, showing 60% stenosis of the mid-distal transplanted renal artery. Interventional radiology successfully stented this lesion, with subsequent improvement in allograft function and blood pressure control. He did not require further intervention in follow-up.

  • acute renal failure
  • renal transplantation
  • renal intervention

Statistics from Altmetric.com

Footnotes

  • Contributors EM and BM were responsible for the planning, conception and design of the case report. EM was responsible for data acquisition and wrote the first draft. RG and BM edited the manuscript and aided in literature review. All authors reviewed and edited the final manuscript for submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.