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Case report
Non-compressive myelopathy: an unusual presentation of a patient with acute B lymphoblastic leukaemia
  1. Avaneesh Shukla1,
  2. Shailendra Prasad Verma1,
  3. Durga Prasad Verma1 and
  4. Geeta Yadav2
  1. 1Clinical Hematology, King George's Medical University, Lucknow, India
  2. 2Pathology, King George's Medical University, Lucknow, India
  1. Correspondence to Dr Shailendra Prasad Verma; spverma1998{at}


A 21-year-old woman was admitted to the department of haematology with fever, generalised body ache and swelling of the feet. She also presented with band-like tightness over the abdomen and was unable to walk for the last 2 days. There was no history of trauma. She was diagnosed as a case of B-cell acute lymphoblastic leukaemia based on flow cytometry and bone marrow studies. MRI of the thoracolumbar spine revealed signal intensity alteration in the spinal cord from D1−2 to D5−6. Her serum vitamin B12 and folate levels were normal. Autoimmune workup including antinuclear antibody and viral serology, and reverse transcriptase PCR for herpes simplex virus, Epstein-Barr virus and cytomegalovirus were negative. Her cerebrospinal fluid was negative for malignant cells. She was started on Berlin-Frankfurt-Munster 95 protocol and her condition improved along with partial improvement in the power of her limbs at the time of discharge. The neurological diagnosis of non-compressive myelopathy due to myelitis was considered.

  • haematology (incl blood transfusion)
  • spinal cord
  • chemotherapy

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  • Contributors AS and SPV have prepared the manuscript and reviewed the literature. DPV helped in writing the manuscript. GY has worked up this case and helped in review of literature.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer-reviewed.

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