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Unusual association of diseases/symptoms
Case report
Polycythaemia following treatment of lymphoplasmacytic lymphoma
  1. Shailendra Prasad Verma1,
  2. Bhupendra Singh1,
  3. Rashmi Kushwaha2 and
  4. Punita Pavecha1
  1. 1Clinical Hematology, King George's Medical University, Lucknow, India
  2. 2Department of Pathology, King George's Medical University, Lucknow, India
  1. Correspondence to Dr Shailendra Prasad Verma; spverma1998{at}gmail.com

Abstract

A 61-year-old man presented to the department of clinical haematology in February 2016 with symptomatic anaemia, generalised lymphadenopathy and hepatomegaly. Routine investigations showed severe anaemia with the presence of lymphoplasmacytoid cells in the peripheral smear, and bone marrow examination with IHC and serum protein electrophoresis confirmed diagnosis of lymphoplasmacytic lymphoma. The patient received supportive transfusion therapy and combination chemotherapy. After VI cycles, the patient had a complete haematological response with marrow in remission. Maintenance rituximab was planned every 3 months for 2 years. At the time of first dose of maintenance rituximab, his haemoglobin (Hb) was 189 g/L with low normal erythropoietin level. During the last 3 years follow-up, his Hb ranged between 16.5 and 20.1 g/dL. All causes of secondary polycythaemia were ruled out. Workup for polycythAemia vera (PV), including JAK-2 and bone marrow, was not suggestive of PV. We labelled it as a case of polycythaemia due to undetermined aetiology.

  • haematology (incl blood transfusion)
  • malignant and benign haematology
  • medical management

https://doi.org/10.1136/bcr-2020-235687

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    Footnotes

    • Contributors SPV and BS have contributed in writing up this case and its discussion. RK has helped in working out this case and PP contributed in data collection and also helping in discussion.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.