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Case report
Interesting case of dual pathology: Crohn’s disease and Peutz-Jeghers syndrome
  1. Mantej Sehmbhi1,2,
  2. Penelope Sellers1,
  3. Jonathan Segal1 and
  4. Susan Clark3
  1. 1Department of Gastroenterology, London North West University Healthcare NHS Trust, London, UK
  2. 2School of Public Health, Imperial College London, London, UK
  3. 3The Polyposis Registry, St Mark’s Hospital, London, UK
  1. Correspondence to Dr Mantej Sehmbhi; mantej.sehmbhi{at}doctors.org.uk

Abstract

An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn’s disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.

  • inflammatory bowel disease
  • Crohn's disease
  • Gastroenterology

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Footnotes

  • Contributors MS, PS and JS reviewed the literature and prepared the manuscript. SC provided critical revisions. All authors have approved the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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