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Case report
Diagnosing inborn error of immunity following the presentation of a complicated acquired infection after MMRV vaccine administration
  1. Lama AlZoebie1,
  2. Hend Al Sereidi2,
  3. Shaima Al Maeeni2 and
  4. Musaab Ramsi2
  1. 1 Pediatrics, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
  2. 2 Paediatric Critical Care Medicine, Shaikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
  1. Correspondence to Dr Musaab Ramsi; musaab.ali{at}


Live vaccine-acquired infection should attest for the occurrence of inborn errors of immunity. Autosomal recessive immunodeficiency 31B, a result of a signal transducer and activator of transcription 1 genetic mutation, results in defected interferon pathways: interferon alpha/beta and interferon gamma. These interferons are crucial for the defence against viral and mycobacterial infections. Recognition is important for preventive and therapeutic approaches. Herein, we report the presentation of a newly diagnosed 13-month-old child with immunodeficiency 31B after presenting with disseminated measles and varicella infection after Measles, Mumps, Rubella and Varicella vaccination.

  • vaccination/immunisation
  • immunology
  • paediatric intensive care
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  • Twitter @Musaabalramsi

  • Contributors LA contributed to writing the discussion and significant revision of all sections. HAS, SAM contributed to acquisition and interpretation of the case report, and writing the presentation. MR contributed substantially to revising the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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