Article Text
Abstract
Multicentric Castleman disease is a rare polyclonal lymphoproliferative disorder mainly associated with two renal manifestations: thrombotic microangiopathy and amyloidosis. Nevertheless, we report here a case of human herpes virus-8 negative multicentric Castleman disease with membranous proliferative glomerulonephritis and extracapillary proliferation. A patient was successfully treated with corticosteroids, anti-CD20 and cyclophosphamide therapy.
- acute renal failure
- proteinurea
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Footnotes
Contributors MBN and F-RD conceived the design of the article, the background and clinical presentation; SR described and analysed the biopsy findings and selected the pictures. MH wrote the differential diagnosis and follow-up. All the authors participated to the discussion. SR, F-RD and MH revised the article.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.