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Case report
Paediatric autoimmune neutropaenia
  1. Joshua Michaels1 and
  2. Anshoo Dhelaria2
  1. 1 Paediatrics, East and North Herts NHS Trust, Stevenage, UK
  2. 2 Paediatrics, Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK
  1. Correspondence to Dr Joshua Michaels; joshuamichaels{at}doctors.org.uk

Abstract

Neutropaenia is defined as an absolute neutrophil count (ANC) of less than 1500 cells/µL and is often divided into mild (ANC: 1000 to 1500 cells/µL), moderate (ANC: 500 to 1000 cells/µL) and severe (ANC: >500 cells/µL) neutropaenia. Autoimmune neutropaenia is arguably one of the most clinically relevant forms of neutropaenia and is defined by an ANC of <500 cells/µL alongside the confirmed presence of anti-neutrophil antibodies. It is a rare subset of neutropaenia boasting an incidence of just 1 in 100 000 infants and is thought to be caused as a result of a ‘surveillance escape event’ of the immune system. This case report identifies key issues in the diagnosis and monitoring of paediatric patients with recurrent neutropaenia and reviews current literature relating to its management in hospital and community settings.

  • paediatrics
  • infant health
  • haematology (incl blood transfusion)
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Footnotes

  • Contributors As author (JM) and co-author (AD), we would like to thank the paediatric department at Lister Hospital for their contribution in data collection and patient record acquisition. The guidance throughout this project, specifically with the planning and conduct of this report, has been greatly appreciated.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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