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A 58-year-old man presented with on and off fever for 1 month. He developed delirium, loss of consciousness and neck rigidity for the last 4 days. On examination, the patient had mild pallor, icterus and splenomegaly (5 cm below the left costal margin). There was no lymphadenopathy. Chest and cardiovascular system examination were normal. Chest X-ray was normal. Sputum examination was negative for acid-fast bacillus (AFB). The patient was HIV and HBs Ag seronegative. Routine Complete Blood Count showed pancytopenia (haemoglobin: 94 g/L, total leucocyte count: 0.46/L, total platelet count: 90×109/L). Peripheral smear showed microcytic hypochromic red blood cells. Cerebrospinal fluid analysis showed lymphocytic pleocytosis with raised adenosine deaminase enzyme level suggestive of tubercular meningitis. Bone marrow aspiration was done for pancytopenia. Marrow was normocellular with marked maturation arrest of granulocytic series. Megakaryocyte number was slightly increased. Marked platelet phagocytosis by histiocytes was noted. There was no evidence of phagocytosis of granulocytic or erythroid cells. Bone marrow biopsy revealed multiple caseating epithelioid cell granulomas with Langhan’s type of giant cells (figure 1). Rod-shaped, red-coloured, slender, beaded AFB, consistent with the morphology of Mycobacterium tuberculosis, were found on Z-N stain. There was minimal fibrosis surrounding the granuloma. Marked leucopenia was explained by maturation arrest in granulocytic series, and the microcytic hypochromic anaemia was attributed to concomitant iron deficiency. The CBC became normal after 3 months of treatment with antitubercular drugs.
Several factors are considered to cause cytopenias in disseminated or extrapulmonary tuberculosis including immune-mediated destruction, hypersplenism, histiocytic hyperplasia, maturational arrest, infiltration of the bone marrow by caseating or noncaseating granulomas causing reversible or irreversible fibrosis.1–3 This case highlights platelet phagocytosis as a significant contributor to peripheral blood thrombocytopenia in tuberculosis. It also emphasises the importance of trephine biopsy for the evaluation of pancytopenia in tuberculosis patients. A bone marrow biopsy may be helpful in distinguishing between various causes of pancytopenia such as antitubercular drug-induced aplastic anaemia, infection-associated haemophagocytic disorder or marrow fibrosis. Delineating the exact causes may help in guiding the therapy.
I was suffering from fever and subsequently lost consciousness and hospitalised. Doctors performed many tests and diagnosed me to be having tuberculosis. My blood cell counts were reducing day by day. My bone marrow examination was done and it was found that tuberculosis has affected my bone marrow and that was the cause of decreased cell counts in my blood. I was treated with antitubercular drugs and my condition improved. I am thankful to the team of doctors who made a timely diagnosis and cured me of my illness.
Tuberculosis may rarely present with thrombocytopenia.
An important cause of thrombocytopenia in tuberculosis is phagocytosis of platelets in the bone marrow.
Bone marrow examination must be routinely done to look for the exact pathogenesis of cytopenia in patients of tuberculosis.
Contributors NS was involved in the drafting of the article, acquisition of images and revising the manuscript. AKA was involved in the addition of data, analysing it, drafting the article and revising it critically for important intellectual content.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Obtained.