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Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Case report
Thrombocytopaenia: a serious side effect of diazoxide
  1. Kirsten A Thus,
  2. Wilhelmina J den Boogert and
  3. Josefine C van der Heyden
  1. Paediatrics, Franciscus Gasthuis en Vlietland, Rotterdam, The Netherlands
  1. Correspondence to Dr Josefine C van der Heyden, j.vanderheyden{at}franciscus.nl

Abstract

A 2.5-year-old boy with a history of (transient) congenital hyperinsulinism was admitted to the paediatric ward with recurrent hypoglycaemia. Diazoxide 5 mg/kg/day and hydrochlorothiazide 2 mg/kg/day were initiated. After increasing the dose of diazoxide to 10 mg/kg/day, the child developed mild rectal bleeding, petechiae, epistaxis and haematemesis. Blood screening showed severe thrombocytopaenia. Diazoxide and hydrochlorothiazide were stopped, and his platelet count normalised. Drug rechallenge was positive. Drug-induced immune thrombocytopaenia was diagnosed.

  • Paediatrics
  • Pharmacology And Therapeutics
  • Haematology (incl Blood Transfusion)
  • Endocrinology

https://doi.org/10.1136/bcr-2019-231222

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    Footnotes

    • KAT and WJB contributed equally.

    • Contributors KAT: selected the patient and contributed to writing the manuscript. WJB contributed to writing the manuscript. JCvdH contributed to patient selection and supervised writing of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Patient consent for publication Parental/guardian consent obtained.