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Case report
Catastrophic antiphospholipid syndrome in pregnancy: a life-threatening condition
  1. Mandy Collict1,
  2. Whitney Sciberras Buhagiar1,
  3. Cecilia Mercieca2 and
  4. John Thake1
  1. 1 Obstetrics and Gynaecology, Mater Dei Hospital, Msida, Malta
  2. 2 Rheumatology, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Ms Mandy Collict, mandycaruana89{at}


Catastrophic antiphospholipid syndrome (CAPS) is a rare and potentially life-threatening variant of the antiphospholipid syndrome which is characterised by multiple small vessel thrombosis which can lead to multiorgan failure. CAPS is a clinical emergency which all clinicians need to be aware of because early diagnosis and treatment may improve maternal and fetal outcome. Here, we report a case of CAPS in pregnancy in a 31-year-old female patient who presented at 28 weeks of gestation. A literature review of CAPS in pregnancy and the puerperium is also included.

  • Rheumatology
  • Pregnancy
  • Drugs And Medicines
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  • Contributors MC wrote this case report and literature review. WSB helped in the write-up of the case and preparation of images. CM did the corrections of the paper and helped in the discussion. JT was involved in the corrections of this case report and the final approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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