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Case report
Atypical haemolytic uremic syndrome secondary to acute pancreatitis: a unique presentation
  1. Jacob Barish,
  2. Pallavi Kopparthy and
  3. Bradley Fletcher
  1. Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Jacob Barish, jacob.barish{at}


Atypical haemolytic uraemic syndrome (aHUS) is a disease of complement dysregulation and can be fatal if not treated in a timely manner. Although normally associated with triggers such as infection or pregnancy, this case demonstrates acute pancreatitis as the triggering event. The patient’s initial presentation of thrombocytopaenia and acute renal failure was first attributed to a systemic inflammatory response syndrome due to pancreatitis, but with detailed history and further laboratory investigation, we were able to show that patient was having symptoms associated with aHUS. On early recognition of aHUS, this patient was able to receive the proper standard of care with eculizumab and had a full recovery while preventing renal failure. When patients present with thrombocytopaenia and renal failure in acute pancreatitis, we want to ensure physicians keep aHUS on the differential.

  • pancreatitis
  • haematology (incl blood transfusion)

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  • Contributors JB and PK were in the primary authors. While BF was the attending physician on the case and was involved with editing and plans for the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.