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Onychocryptosis and asymptomatic external urethritis as complications of oral isotretinoin therapy
  1. Krishan Sivaraj1,
  2. Jessica Friedman1 and
  3. Dean Morrell2
  1. 1 Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  2. 2 Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  1. Correspondence to Krishan Sivaraj, krishan_sivaraj{at}


This case report presents a patient who, while undergoing oral isotretinoin therapy for acne vulgaris, developed onychocryptosis and asymptomatic external urethritis. These uncommon adverse events are not well-documented in medical literature. While his urethritis spontaneously resolved, his onychocryptosis symptoms necessitated surgical intervention. This report illustrates both cosmetic and functional adverse effects of isotretinoin and provides insight into the progression of these reactions over time.

  • dermatology
  • skin
  • unwanted effects / adverse reactions
  • general practice / family medicine
  • urinary and genital tract disorders

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  • Contributors JF and KS initially evaluated the patient. JF conceived of the idea for the report. KS wrote the manuscript with support from JF and DM. All authors contributed to and approved the final version of the report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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