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High-grade B-cell lymphoma masquerading as peritoneal lymphomatosis
  1. Samuel Kareff1,
  2. Chao Yin1 and
  3. John Feigert2
  1. 1 MedStar Georgetown University Hospital, Washington, DC, USA
  2. 2 Virginia Cancer Specialists, Arlington, Virginia, USA
  1. Correspondence to Dr Samuel Kareff, samuel.a.kareff{at}


Peritoneal lymphomatosis represents a rare presentation of any type of non-Hodgkin’s lymphoma, with relatively few cases reported in the literature. We present here the case of a 61-year-old man who originally presented with increased abdominal distention associated with shortness of breath and diaphoresis who was found to have evidence of peritoneal carcinomatosis on CT scan. Biopsy confirmed diffuse large B-cell lymphoma, and the working diagnosis was subsequently modified to peritoneal lymphomatosis. The patient was treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) therapy with initially good response. His course was complicated by tumour lysis syndrome. We review the limited literature discussing peritoneal lymphomatosis and discuss the importance of facilitating rapid and efficacious treatment.

  • oncology
  • radiology
  • cancer intervention
  • malignant and benign haematology
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  • Contributors SK, CY and JF participated equally in the clinical care of this patient. SK and CY jointly created the manuscript and its contents. JF supervised the production of the manuscript and provided edits as necessary.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

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