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Calciphylaxis due to metastatic well-differentiated neuroendocrine carcinoma
  1. Summia Matin Afridi1,
  2. Ahmad Raja2,
  3. Xia Zhou1 and
  4. Akriti Jain1
  1. 1 Internal Medicine, Florida Hospital Orlando, Orlando, Florida, USA
  2. 2 Internal Medicine, Presence Saint Francis Hospital, Evanston, Illinois, USA
  1. Correspondence to Dr Summia Matin Afridi, summiamatin{at}


A 70-year-old man with history of metastatic well-differentiated neuroendocrine carcinoma was presented to the hospital with a painful left lower extremity ulcer which started around 3 months prior to presentation. He was treated with antibiotics for cellulitis on multiple occasions with no improvement in his symptoms. On initial laboratory evaluation, he was found to have acute kidney injury and a normal calcium level. The patient underwent a skin biopsy and was found to have cellulitis and calciphylaxis of small-sized and medium-sized vessels. Since the patient did not have any underlying risk factors of calciphylaxis, the most likely cause of his calciphylaxis was thought to be his underlying malignancy. Physicians should keep this differential in mind while treating non-healing ulcers in such patients since they are at higher risk of superimposed infections and usually require aggressive wound care.

  • dermatology
  • infections
  • skin
  • endocrine cancer
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  • Contributors SMA: draft preparation, data collection, reviewing the article before submission for grammar and intellectual content, supervising and organising the course of the manuscript. AR: construction of ideas, final approval of document for grammar and intellectual content and literature review. XZ: obtaining consent, directly involved in patient care, writing manuscript, patient follow-up and final approval of document. AJ: literature review, construction of the manuscript, data management and final approval of document.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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