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Paediatric severe chronic spontaneous urticaria: successful management through conventional drug therapy
  1. Dimitri Poddighe1,2,
  2. Ilaria Brambilla2,3,
  3. Amelia Licari2,3 and
  4. Gian Luigi Marseglia2,3
  1. 1 Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan City, Kazakhstan
  2. 2 Department of Pediatrics, Universita' degli Studi, Pavia, Italy
  3. 3 Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  1. Correspondence to Professor Gian Luigi Marseglia, gl.marseglia{at}


Chronic spontaneous urticaria (CSU) can occur in children and the clinical management is quite challenging. Here, we described a paediatric clinical case of CSU successfully managed by conventional therapy, including systemic steroids, cetirizine, anti-leukotriene drug and dietary restriction (for histamine-releasing foods). This patient showed neither atopy nor any allergic sensitisation; moreover, the autologous serum skin test resulted negative. This category of patients with no comorbidity and no evidence of atopy might benefit from the conventional drug management; however, a protracted course of steroid treatment with very slow and gradual tapering may be needed. This approach was successful and safe in our clinical case, but a careful follow-up, due to the potential side effects of steroids, should be recommended.

  • paediatrics (drugs and medicines)
  • medical management
  • dermatology
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  • Contributors DP managed the patient. DP conceived and wrote the article. AL and IB helped in writing the article. GLM provided intellectual contribution.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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