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Aggressive type of central giant cell granuloma in a woman on hormone replacement therapy: a histopathological insight
  1. Swati Gautam1,
  2. Meetkamal Grewal2,
  3. Nitin Saini3 and
  4. Karandeep Singh Arora4
  1. 1 Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, India
  2. 2 Department of Oral Pathology and Microbiology, BRS Dental College and Hospital, Panchkula, India
  3. 3 Department of Oral Pathology and Microbiology, Himachal Institute of Dental Sciences, Sirmour, India
  4. 4 Oral Medicine and Radiology, Maharishi Markandeshwar College of Dental Sciences and Research, Ambala, India
  1. Correspondence to Dr Karandeep Singh Arora, drkaranarora{at}


Quite a few lesions of the oral cavity specifically of the gingiva have a greater inclination towards women and mostly occur during the first four decades of life, the cause of which may be credited to the changing levels of sex hormones. Out of all such lesions, one lesion whose aetiology is still unclear and which originats from the periosteum or periodontal ligament is central giant cell granuloma. Repeatedly, it is has been described as a reactive lesion, the cause of which may be secondary to local irritants or trauma, specifically plaque or calculus, which is not considered to be a true neoplasm. Here we present a case of a 51-year-old female patient with aggressive gingival growth within 10–13 months of hormonal replacement therapy. The aetiology, histological features and appropriate treatment are discussed in the light of current literature.

  • dentistry and oral medicine
  • endocrine system

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  • Contributors SG was responsible for concept, design, contents, literature, histopathological diagnosis, manuscript preparation. MG was responsible for design, contents, literature review, histopathological analysis and manuscript editing. NS was responsible for literature search, data analysis, data compilation, manuscript drafting. KSA was responsible for evaluation of radiographs, literature search, manuscript editing, manuscript reviewing. All the authors had approved the final draft of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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