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Diffuse melanosis cutis: a rare manifestation of metastatic melanoma
  1. Brian Chinai1,
  2. Michael Piazza1,
  3. Ritesh Patel1 and
  4. Satyajeet Roy2
  1. 1 Cooper University Hospital, Camden, New Jersey, USA
  2. 2 Internal Medicine, Cooper University Hospital, Cherry Hill, New Jersey, USA
  1. Correspondence to Dr Brian Chinai, chinai-brian{at}, brianchinai17{at}


Diffuse melanosis cutis (DMC) is an extremely rare and late complication of metastatic melanoma (MM). It involves the progressive blue-grey discolouration of the skin and mucous membranes, occurring approximately 1 year after diagnosis of MM. The pathogenesis of DMC is unknown, although specific growth factors, such as alpha-melanocyte stimulating hormone, hepatocyte growth factor and endothelin-1, released by cancer cells, along with release of melanin precursors in the bloodstream and dermal MM micrometastases producing melanin have been attributed. Even with appropriate therapy, DMC seems to be a poor prognostic factor, with a mean survival time of 4–5 months. Here, we report a case of BRAF-mutated MM who presented with DMC. The patient underwent BRAF/MEK inhibition followed by anti-PDL1 therapy, yet passed away approximately 1 year after diagnosis.

  • cancer intervention
  • dermatology
  • skin cancer

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  • Contributors BC designed, implemented and finalised the manuscript. MP provided literature search. RP and SR revised the manuscript. All contributors refined and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.

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