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Thymoma-associated multiorgan autoimmunity
  1. Chien-Tzu Hung1,
  2. Tsen-Fang Tsai2,
  3. Jin-Shing Chen1 and
  4. Min-Shu Hsieh3,4
  1. 1 Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
  2. 2 Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan
  3. 3 Department of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan
  4. 4 Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan
  1. Correspondence to Dr Jin-Shing Chen, chenjs{at}


Thymoma-associated multiorgan autoimmunity is a relatively new term to describe the rare paraneoplastic syndrome that complicates thymoma, which can involve the thyroid, liver and intestine in addition to the skin. The pathology often indicates a graft-versus-host-like pattern commonly observed in recipients of an allogeneic haematopoietic cell transplant. We report a case of type B2 and B3 thymoma with invasion to the lung and pleura in a patient who presented with oral lichen planus and graft-versus-host-like erythroderma. The cutaneous lesions improved after complete resection of the thymoma in combination with systemic glucocorticoids, which was subsequently complicated by cytomegalovirus pneumonitis.

  • cardiothoracic surgery
  • dermatology

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  • Contributors Conception and design of the work: C-TH, J-SC. Data collection: C-TH, J-SC. Data analysis and interpretation: C-TH, J-SC. Drafting the article: C-TH. Critical revision of the article: T-FT, M-SH. Final approval of the article: C-TH, J-SC, T-FT, M-SH.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None to declare

  • Ethics approval This case report was waived for ethics approval.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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