Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition.
- musculoskeletal and joint disorders
- therapeutic indications
- connective tissue disease
- musculoskeletal syndromes
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Contributors TG wrote the article and followed the patient’s case. LS corrected the case, interpreted the data and also followed the patient afterwards.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Obtained.