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Macitentan in the treatment of severe digital ulcers
  1. Tatiana Gonçalves1,2 and
  2. Lèlita Santos1,2,3
  1. 1 Internal Medicine Service, Coimbra Hospital and University Centre, Coimbra, Portugal
  2. 2 Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  3. 3 CIMAGO Research Centre, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  1. Correspondence to Dr Tatiana Gonçalves, tatianafgoncalves90{at}


Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition.

  • musculoskeletal and joint disorders
  • skin
  • therapeutic indications
  • connective tissue disease
  • musculoskeletal syndromes

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  • Contributors TG wrote the article and followed the patient’s case. LS corrected the case, interpreted the data and also followed the patient afterwards.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.