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CASE REPORT
Duodenal neuroendocrine tumour associated with minimal change glomerulonephritis
  1. Emily Montague1,
  2. Kimberley Hockenhull1,
  3. Angela Lamarca1,
  4. Tamer Al-Sayed2 and
  5. Richard A Hubner1
  1. 1 Medical Oncology, Christie NHS Foundation Trust, Manchester, UK
  2. 2 Acute/Renal Medicine, Christie NHS Foundation Trust, Manchester, UK
  1. Correspondence to Dr Emily Montague, emily.montague{at}doctors.org.uk

Abstract

Paraneoplastic glomerular disease is an increasingly well-recognised entity, and a wide range of both solid and haematological malignancies have been implicated. The most common glomerular disease associated with cancer is membranous nephropathy. Only a few case reports have described an association between neuroendocrine tumours (NETs) and glomerulonephritis and only one paediatric case in relation to minimal change disease. A 76-year-old woman with a well-differentiated duodenal NET presented with nephrotic syndrome and renal biopsy was suggestive of minimal change glomerulonephritis. Standard therapy with corticosteroids brought little benefit, but a dramatic improvement was seen following initiation of systemic anticancer therapy with lanreotide, a somatostatin analogue. Less than 1 month after initiation of lanreotide, the patient was no longer in a nephrotic state, and after a further 2 months of follow-up had shown no sign of relapse.

  • endocrine cancer
  • nephrotic syndrome
  • proteinurea
  • small intestine cancer
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Footnotes

  • Contributors EM, KH and RAH contributed to the conception and design of the article. Drafting and data collection and analysis were done by EM. KH, RAH, AL and TA-S contributed to revisions and approved the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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