Description

A 58-year-old man presented to the hospital with a 1-week history of dyspnea, cough, purulent sputum, fever and malaise. Patient had known HIV−1 infection for 10 years, with nadir CD4⁺ count of 31/µL and history of pneumocystosis as single opportunistic infection. He was under antiretroviral therapy (lamivudine and darunavir/ritonavir). Comorbidities included emphysema and history of tobacco, alcohol, cocaine and heroin abuse, now abstinent for several years. He presented with type 2 respiratory failure, neutrophilic leukocytosis and increased C-reactive protein (350 mg/L); CD4⁺ count was 212/µL and HIV viral load was undetectable. Chest radiograph revealed a large right-sided pulmonary cavity with dependent air-fluid level (figure 1A). CT confirmed the presence of a thick-wall cavity in the right inferior lobe with a major axis of 8.6 cm (figure 1B,C). Findings were consistent with diagnosis of a large pulmonary abscess and patient was started on empirical therapy with meropenem. Sputum cultures revealed growth of an extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Pseudomonas aeruginosa. Fluorescent microscopy and cultures of sputum were negative for mycobacteria. Meropenem was kept for 3 weeks with resolution of symptoms, respiratory failure and laboratory anomalies. A 3-week control CT scan showed downsizing of abscess dimensions while sputum cultures were now consistently negative. At this time, due to infection risk associated with maintenance of a central line in a patient without peripheral venous access, and the interest in switching to an outpatient regimen, treatment was changed to intramuscular ertapenem. Patient was under carbapenem therapy for a total of 8 weeks. Chest radiograph and CT scan at the end of treatment showed a smaller lesion with thin walls and without liquid component (figure 2A–C).

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Figure 1

Chest X-ray (A) and CT scan (B and C) at admission, showing a large right-sided pulmonary cavity with dependent air-fluid level.

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Figure 2

Chest X-ray (A) and CT scan (B and C) after 8 weeks of antibiotic therapy, showing a smaller lesion with thin walls and without liquid component.

Lung abscesses in patients with cell-mediated immune defects have a particular range of microbial flora, including bacteria, mycobacteria and fungi.1 The most common bacterial agents include P.aeruginosa, Enterobacteriaceae and anaerobes. Lung abscesses are often polymicrobial infections and anaerobes are difficult to isolate in sputum cultures. Empirical antibiotic options include clindamycin, β-lactam/β-lactamase-inhibitor combinations, carbapenems and quinolones with anaerobic activity.2 Meropenem was chosen because of its good penetration in lung parenchyma, and to target both anaerobes and multidrug-resistant aerobes (as patient had structural lung disease). Treatment duration is controversial; some authors advocate a standard regimen of 3–6 weeks.3 4 In this case, after 3 weeks of meropenem therapy with general improvement, it was considered safe to switch to intramuscular ertapenem, allowing an outpatient regimen. It was chosen instead of oral antimicrobials because of the interest in prolonging antibiotic coverage for ESBL-producing E.coli, in addition to anaerobes. However, ertapenem presents limited activity against Pseudomonas; patient was kept under close surveillance and, as outcome was favourable, previous 3-week treatment was considered adequate for this agent. Pharmacokinetics of intramuscular ertapenem are similar to intravenous administration in terms of area under the concentration curve and duration over which plasma levels exceed the susceptibility breakpoint.5 Total duration of treatment was determined by clinical and imaging response, and it was kept until CT scan showed a small, stable and residual lesion.