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Non-typhoidal salmonellosis presenting as acute calculus cholecystitis
  1. Fatema Juma1,
  2. Joshua J Cave2,
  3. Hector Gonzales2 and
  4. Luke Stephen Prockter Moore3,4,5
  1. 1 London North West University Healthcare NHS Trust , Harrow, UK
  2. 2 Department of General Surgery, Chelsea and Westminster NHS Foundation Trust, London, UK
  3. 3 Department of Microbiology, Imperial College Healthcare NHS Trust, London, UK
  4. 4 HPRU in Healthcare Associated Infection and Antimicrobial Resistance, Imperial College London, London, UK
  5. 5 Clinical Infection Department, Chelsea & Westminster NHS Foundation Trust, London, UK
  1. Correspondence to Dr Luke Stephen Prockter Moore, luke.moore{at}


Non-typhoidal Salmonella spp.are Gram-negative bacilli, which typically cause a clinical picture of gastroenteritis and, less commonly, patients may become a chronic carrier of the pathogen within their gallbladder. We describe a rare clinical presentation of a non-typhoidal Salmonella spp. infection as acute calculus cholecystitis in an adult patient. Salmonella enterica subsp. Salamae (ST P4271) was grown from cholecystostomy fluid, and the patient subsequently underwent a laparoscopic cholecystectomy that demonstrated a necrotic gallbladder fundus. We advise that microbiological sampling of bile is essential, especially in the context of foreign travel, to detect unusual pathogens as in this case or common pathogens that may have unusual antimicrobial resistance. Given the necrotic gallbladder as in this case, we also advise that early cholecystectomy should be strongly considered in these patients.

  • general surgery
  • pancreas and biliary tract
  • infectious diseases
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  • FJ and JJC contributed equally.

  • Contributors FJ and JJC conducted the literature search and drafted the initial manuscript. HG and LSPM wrote sections relevant to their areas of expertise and reviewed redrafts of the manuscript. All authors agreed the final submitted version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Disclaimer The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the UK Department of Health.

  • Competing interests LSPM has consulted for bioMerieux (2013), DNAelectronics (2015) and Dairy Crest (2017–2018); received speaker fees from Profile Pharma (2018) and Pfizer (2018-2019); received research grants from the NIHR (2013–2018) and Leo Pharma (2016); and received educational support from Eumedica (2016–2017).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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