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Diffuse large B-cell lymphoma recurrence presenting as multiple, progressive cranial neuropathies
  1. Abby R Goron1,
  2. Stephen Devlin1 and
  3. Stacy Schwartz2
  1. 1 University of Maryland School of Medicine, Baltimore, Maryland, USA
  2. 2 Internal Medicine, University of Maryland Baltimore, Baltimore, Maryland, USA
  1. Correspondence to Dr Stacy Schwartz, stacy.schwartz{at}


A 58-year-old man with a history of rheumatoid arthritis and stage IV diffuse large B-cell lymphoma, in complete remission with no evidence of residual disease on positron emission tomography/CT after completing six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy, presented with acute onset of dysphagia to solids and liquids. On further evaluation, his dysphagia was attributed to a vagus nerve palsy, and later during his admission, he developed rapidly progressing left facial and vestibulocochlear nerve palsies. Imaging studies displayed pathological enhancement of bilateral seventh and eighth cranial nerves, concerning for leptomeningeal recurrence of lymphoma. Cerebrospinal fluid analysis and flow cytometry were confirmatory, revealing markedly atypical monotypic CD19 positive B cells.

  • oncology
  • cranial nerves
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  • Contributors SS is the guarantor, accepts full responsibility for the work and conduct of this case report. She was the primary attending physician caring for the patient during his admission, diagnosis and initial hospitalisation and the one who identified and managed the case. SD and ARG were the medical students responsible for assisting with this patient’s care during his initial hospitalisation. They conducted a literature review, wrote and prepared the manuscript for submission, with frequent input and editorial support by SS.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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