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Guillain-Barre syndrome with concurrent posterior reversible encephalopathy syndrome and hyponatraemia: mere coincidence or rare coexistence
  1. Carley Drye1,
  2. Subhasish Bose2,
  3. Samata Pathireddy3 and
  4. Narothama Reddy Aeddula3,4
  1. 1 Medicine, Liberty University, Lynchburg, Virginia, USA
  2. 2 Nephrology, Lynchburg Nephrology, Lynchburg, Virginia, USA
  3. 3 Medicine, Deaconess Health System, Evansville, Indiana, USA
  4. 4 Medicine, Indiana University School of Medicine, Evansville, USA
  1. Correspondence to Dr Samata Pathireddy, drspathireddy{at}


A 61-year-old Caucasian woman with a history of hypertension presented with a week’s history of confusion falls and back pain was found to have hyponatraemia from secretion of antidiuretic hormone and treated appropriately. Given her persistent symptoms, despite a normal CT head on presentation, an MRI head was obtained, showing vasogenic oedema in line with posterior reversible encephalopathy syndrome (PRES). Despite aggressive antihypertensives and supportive measures, unfortunately, her condition deteriorated, with increased confusion, new left-sided flaccid paresis, paraesthesias and worsening of the back pain. Following further testing including a cerebrospinal fluid analysis, finally diagnosed with an atypical presentation of Guillain-Barre syndrome (GBS), and prompt management with intravenous immunoglobulins was initiated. She recovered clinically and returned to near-normal function on follow-up. We use this case to suggest the importance of dysautonomia in GBS and various clinical manifestations it can present with, including PRES and hyponatraemia.

  • clinical neurophysiology
  • fluid electrolyte and acid–base disturbances
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  • Contributors CD and SB are involved in the planning, conception, acquisition of clinical data and helped with the drafting of the case report. SP and NRA have assisted with data collection, literature review and final preparation of the manuscript. CD and SB are the first authors and have equally contributed to the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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