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Proton beam therapy for malignant transformation of intracranial epidermoid cyst
  1. Zhe Chen1,
  2. Masayuki Araya2 and
  3. Hiroshi Onishi1
  1. 1 Radiology, University of Yamanashi Faculty of Medicine, Chuo, Yamanashi, Japan
  2. 2 Proton Therapy Centre, Aizawa Hospital, Matsumoto, Nagano, Japan
  1. Correspondence to Dr Zhe Chen, z.chenmd{at}


We report the first clinical case on the successful use of proton beam therapy in the management of malignant transformation of intracranial epidermoid cyst. A 43-year-old man was initially diagnosed as this disease with left facial paresis, hypesthesia and hypoalgesia in the territories of the trigeminal nerve. After failure of surgical interventions, he was referred to our radiation centre. We performed a postoperative proton beam therapy for treatment. We delivered a total dose of 57 GyE in 31 fractions. He tolerated the treatment well with mild acute toxicities and remained healthy and functional by 2-year follow-up postradiotherapy. No evidence of delayed radiation-induced neurotoxicity was observed.

  • radiology
  • neurooncology
  • neurosurgery
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  • Contributors MA and ZC contributed to conception and design of study. ZC contributed to acquisition of data and drafted the manuscript. HO revised the manuscript critically for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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