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McCune Albright syndrome: an endocrine medley
  1. Remya Rajan,
  2. Kripa Elizabeth Cherian,
  3. Hesarghatta Shyamsunder Asha and
  4. Thomas Vizhalil Paul
  1. Department of Endocrinology, Christian Medical College, Vellore, Tamil Nadu, India
  1. Correspondence to Dr Kripa Elizabeth Cherian, kripaec{at}


McCune Albright syndromeis a rare disorder that presents with multiple endocrine abnormalities. We report the case of a 24-year-old woman who presented with right lower limb pain, with no preceding trauma or fracture. On examination she was noted to have coarsened facial features, acral enlargement, bitemporal hemianopia, galactorrhoea and multiple café-au-lait macules. She gave history of precocious puberty, having attained menarche at 7 years of age. Biochemical investigations revealed hyperprolactinaemia, with unsuppressed growth hormone levels following a glucose load and subclinical hyperthyroidism. Technetium-99m methylene diphosphonate bone scan showed polyostotic fibrous dysplasia, MRI of the brain showed a pituitary macroadenoma. Thus she was diagnosed to have McCune Albright syndrome with multiple endocrine manifestations. She was treated with parenteral zoledronate for her bony lesions and initiated on cabergoline for plurihormonal pituitary macroadenoma. She is planned to be on close follow-up to assess for clinical improvement and appearance of other manifestations.

  • pituitary disorders
  • thyroid disease
  • calcium and bone

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  • Contributors RR and KEC wrote the manuscript. HSA and TVP reviewed and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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