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CASE REPORT
Spontaneous regression of conjunctival keratoacanthoma
  1. Ghada J AlBayyat1,
  2. Nandini Venkateswaran1,
  3. Dan Arreaza1,
  4. Sander R Dubovy1,2,3,
  5. Anat Galor1,4 and
  6. Carol L Karp1
  1. 1 Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA
  2. 2 Florida Lions Ocular Pathology Laboratory, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA
  3. 3 Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL, USA
  4. 4 Department of Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL, USA
  1. Correspondence to Dr Carol L Karp, ckarp{at}med.miami.edu

Abstract

An 83-year-old white man presented with a rapidly growing conjunctival mass in his left eye over the course of 1 month. While awaiting surgical intervention, the tumour underwent partial, spontaneous regression to half its original size. The lesion was ultimately excised with wide margins using a no-touch technique and application of cryotherapy to the corneal and conjunctival margins and scleral bed. Histopathological analysis revealed a conjunctival keratoacanthoma. To our knowledge, this is the first case documenting the partial, spontaneous regression of a conjunctival keratoacanthoma over a 5 week time course from the time of diagnosis to surgical excision.

  • ophthalmology
  • anterior chamber
  • pathology
  • oncology
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Footnotes

  • Contributors GJA: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project. NV: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project. DA: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project. SRD: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project. AG: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project. CLK: this author was involved in the planning, conception and design, acquisition of data, analysis and interpretation of data and reporting of this project.

  • Funding NIH Center Core Grant P30EY014801, RPB Unrestricted Award and Career Development Awards, Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research EPID-006-15S (Dr Galor), R01EY026174 (Dr Galor), The Dr Ronald and Alicia Lepke Grant, The Lee and Claire Hager Grant, The H. Scott Huizenga Grant, The Grant and Diana Stanton-Thornbrough, The Robert Baer Family Grant, The Emilyn Page and Mark Feldberg Grant, The Jose Ferreira de Melo Grant, Richard and Kathy Lesser Grant, The Ted and Michele Kaplan Grant and the Richard Azar Family Grant (institutional grants).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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