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Pathological fracture of non-ossifying fibroma associated with neurofibromatosis type 1
  1. James Ritchie Gill1,
  2. Tamer Magid EL Nakhal1,
  3. Soo-Mi Park2 and
  4. Mariusz Chomicki1
  1. 1 Trauma and Orthopaedics, Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough, Cambridgeshire, UK
  2. 2 Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK
  1. Correspondence to Mr James Ritchie Gill, james.ritchie.gill{at}


We report the management of a pathological fracture through a proximal tibial non-ossifying fibroma (NOF) in a 13-year-old girl with neurofibromatosis type 1 (NF1). The fracture was minimally displaced, and the lesion had clinical features of a NOF, and therefore biopsy was not required. Operative fixation has been the preferred method of treatment for pathological fractures through NOF associated with NF1. Multiple NOFs associated with NF1 are rare but can coalesce resulting in large lesions with an increased risk of pathological fracture. In cases which permit, non-operative treatment with cast immobilisation can yield satisfactory results.

  • orthopaedics
  • accidents
  • injuries
  • knee injuries

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  • Contributors JRG: gathered data and imaging and prepared the manuscript. TMELN: gathered data, performed literature search and prepared the manuscript. S-MP and MC: responsible for conception and design of the case report as well as editing manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

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