Article Text

Download PDFPDF

Bilateral graft emphysematous pyelonephritis
  1. Shanmugasundaram Rajaian,
  2. Murugavaithianathan Pragatheeswarane,
  3. Karrthik Krishnamurthy and
  4. Lakshman Murugasen
  1. MIOT International, Chennai, Tamil Nadu, India
  1. Correspondence to Dr Shanmugasundaram Rajaian, ssrl25{at}gmail.com

Statistics from Altmetric.com

Description

Emphysematous pyelonephritis (EPN) in a postrenal transplantation state is a rare condition and associated with high morbidity.1 2 Conservative management with antibiotics and percutaneous drainage is successful in majority of the patients,3 but severe forms of disease at presentation carries high mortality.2 A 44-year-old male patient presented with history of breathlessness and fever with chills of 1-day duration. He is known to have diabetes, hypertension and coronary artery disease. He underwent live-related renal transplant in 2005, which got rejected in 2017. He had second live-related renal transplant in 2017, which also got rejected due to chronic pyelonephritis. He was on maintenance haemodialysis for the past 3 months. On examination, he had fever of 39°C, pulse rate of 120/min and blood pressure of 90/60 mm Hg. He had lower abdomen tenderness, and the rest of the examination was normal. His blood investigations revealed total count of  24.5×109, random blood sugar—342 mg/dL, serum creatinine—5.2 mg/dL, haemoglobin—72 g/L, while rest of the parameters were normal. Escherichia coli was grown from the urine culture. He underwent CT scan of the abdomen which revealed bilateral emphysematous graft pyelonephritis with air in the bladder (figure 1). He was catheterised with 18 Fr Foley, which drained 50 mL of purulent urine. He was started on injection meropenem 500 mg intravenously two times per day and insulin on sliding scale basis, but his clinical condition did not improve even after 24 hours. He underwent early bilateral subcapsular graft nephrectomy (figure 2). Culture of tissue from phlegmon has also grown E. coli. He was on maintenance haemodialysis in the postoperative period. His postoperative period was uneventful, and he was discharged in stable condition on the fifth postoperative day.

Figure 1

(A) CT scan revealing gas in right kidney (hollow arrow) and perinephric fat stranding (asterisk). (B) CT scan depicting gas in the bilateral renal pelvis (hollow arrow). (C) CT scan revealing gas in the urinary bladder (hollow arrow).

Figure 2

(A) Intraoperative picture of right kidney with pus flakes (asterisk). (B) Gross specimen of right subcapsular nephrectomy. (C) Intraoperative picture of phlegmon surrounding left kidney (hollow arrow). (D) Gross specimen of left kidney with adherent phlegmon.

EPNs affecting transplant kidneys are rare with only 29 cases reported in the literature.4 Clinical presentation is also subdued due to denervated graft kidneys and immunosuppressive state.4 Uncontrolled diabetes and immunosuppressive drugs makes this population more susceptible for allograft infection. Allograft EPN is associated with higher mortality, graft loss and permanent dialysis.4 CT is the gold standard for diagnosing this condition, and different management algorithms are proposed.4 Newer staging system as proposed by Al-Geizawi has taken both anatomical and septic components of the disease process into account for the management guidelines.1 Recent studies have shown that medical management with percutaneous drainage have the lowest complication and increased chances of graft salvage.5 6 In our case as the patient was already on maintenance haemodialysis for chronic allograft rejection, we did not attempt for double J stenting or percutaneous drainage. Though conservative management with antibiotics and percutaneous drainage is successful in majority of the patients,3 severe forms of disease at presentation carry a high mortality even when nephrectomy is performed.2 As the literature regarding EPN in graft kidneys is scarce, the patient’s clinical signs and severity of presentation should decide the line of management rather than strictly adhering to a grading system.2 We conclude that a higher grade of disease staging at presentation should have a lower threshold for performing nephrectomy to reduce mortality.

Learning points

  • Percutaneous drainage and intravenous antibiotics are acceptable treatment options, but in severe cases or those refractory to treatment, nephrectomy is the appropriate treatment.

  • Treatment should be individualised as the literature and guidelines are scarce.

References

Footnotes

  • SR and MP contributed equally.

  • Contributors SR and LM examined the patient and collected data. MP conceptualised and designed the study and written the manuscript. KK analysed and reviewed the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Obtained.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.